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Herzner, A. M., J. Dischinger, C. Szekat, M. Josten, S. Schmitz, A. Yakeleba, R. Reinartz, A. Jansen, H. G. Sahl, J. Piel, and G. Bierbaum. 2011. Expression of the lantibiotic mersacidin in Bacillus amyloliquefaciens FZB42. PLoS. One. 6:e22389. Heinrich, N., A. Mueller, P. Bartmann, A. Simon, G. Bierbaum, and S. Engelhart. 2011. Successful management of an MRSA outbreak in a neonatal intensive care unit. Eur. J Clin. Microbiol Infect. Dis. 30:909-913. Nagel, M., T. Reuter, A. Jansen, C. Szekat, and G. Bierbaum. 2011. Influence of ciprofloxacin and vancomycin on mutation rate and transposition of IS256 in Staphylococcus aureus. Int. J Med Microbiol 301:229-236. Schäberle, T. F., E. Goralski, E. Neu, O. Erol, G. Holzl, P. Dormann, G. Bierbaum, and G. M. König. 2010. Marine myxobacteria as a source of antibiotics--comparison of physiology, polyketide-type genes and antibiotic production of three new isolates of Enhygromyxa salina. Mar. Drugs 8:2466-2479. Dischinger J, Josten M, Szekat C, Sahl HG, Bierbaum G. 2009. Production of the novel two-peptide lantibiotic lichenicidin by Bacillus licheniformis DSM 13. PLoS One. 2009 Aug 26;4(8):e6788. Marklein G, Josten M, Klanke U, Müller E, Horré R, Maier T, Wenzel T, Kostrzewa M, Bierbaum G, Hoerauf A, Sahl HG. 2009. Matrix-assisted laser desorption ionization-time of flight mass spectrometry for fast and reliable identification of clinical yeast isolates. J Clin Microbiol. 2009 Sep;47(9):2912-7. Epub 2009 Jul 1. Appleyard AN, Choi S, Read DM, Lightfoot A, Boakes S, Hoffmann A, Chopra I, Bierbaum G, Rudd BA, Dawson MJ, Cortes J. 2009. Dissecting structural and functional diversity of the lantibiotic mersacidin. Chem Biol. 2009 May 29;16(5):490-8. Bierbaum G, Sahl HG. 2009. Lantibiotics: mode of action, biosynthesis and bioengineering. Curr Pharm Biotechnol. 2009 Jan;10(1):2-18. Sass, P., and G. Bierbaum. 2009. Native graS mutation supports the susceptibility of Staphylococcus aureus strain SG511 to antimicrobial peptides. Int J Med Microbiol. 2009 Jun;299(5):313-22. Epub 2009 Jan 9. Sass, P., A. Jansen, C. Szekat, V. Sass, H.G. Sahl, G. Bierbaum. 2008. The lantibiotic mersacidin is a strong inducer of the cell wall stress response of Staphylococcus aureus. BMC Microbiol. 8(1):186. Sass, V., U. Pag, A. Tossi, G. Bierbaum, and H. G. Sahl. 2008. Mode of action of human β-defensin 3 (hBD3) against Staphylococcus aureus and transcriptional analysis of responses to defensin challenge. Int. J. Med. Microbiol. 298: 619-633. Bagci, S., A.M. Eis-Hübinger, A.R. Franz, G. Bierbaum, A. Heep, O. Schildgen, P. Bartmann, B. Kupfer, A. Mueller. 2008. Detection of astrovirus in premature infants with necrotizing enterocolitis. Pediatr Infect Dis J. 2008 Apr;27(4):347-50. Bonness, S., C. Szekat, N. Novak and G. Bierbaum. 2008. Pulsed field gel electrophoresis of Staphylococcus aureus isolates from atopic patients reveals presence of similar strains on the children and their parents. J. Clin. Microbiol. 46: 456-461. Hübscher, J., A. Jansen, O. Kotte, J. Schäfer, P. A. Majcherczyk, L. G. Harris, G. Bierbaum, M. Heinemann and B. Berger-Bächi. 2007. Living with an imperfect cell wall: Compensation of femAB inactivation in Staphylococcus aureus. BMC Genomics 8:307. Bierbaum, G., Jansen, A. 2007. Tying the knot: making of lasso peptides. Chem. Biol. 14:734-735. Simon, A., G. Bierbaum, S. Engelhart, M. Exner, M. Kramer, U. Bode, G. Fleischhack and the study group Onkopaed 2001. 2007. Nosocomial Clostridium difficile-associated disease in pediatric cancer patients - results from prospective German surveillance study. Hygiene und Medizin 32, 177-18. Becker, K., G. Bierbaum, C. von Eiff, S. Engelmann, F. Götz, J. Hacker, M. Hecker, G. Peters, R. Rosenstein, and W. Ziebuhr. 2007. Understanding the physiology and adaptation of staphylococci: A post-genomic approach. Int. J. Med. Microbiol. 297: 483-501. Jansen, A., M. Türck, C. Szekat, M. Nagel, I. Clever, and G. Bierbaum. 2007. Role of insertion elements and yycFG in the development of decreased susceptibility to vancomycin in Staphylococcus aureus. Int. J. Med. Microbiol. 297:205-215 Rayani, A., U. Bode, E. Habas, G. Fleischhack, S. Engelhart, M. Exner, O. Schildgen, G. Bierbaum, A.-M. Eis-Hübinger, and A. Smith. 2007. Rotavirus infections in paediatric oncology patients: A matched-pairs analysis. Scand. J. Gastroenterol. 42:81-87. Sass, P., and G. Bierbaum. 2007. Lytic activity of recombinant phage {phi}11 and {phi}12 endolysins on whole cells and biofilms of Staphylococcus aureus. Appl. Environ. Microbiol. 73:347-352. Schmitz, S., A. Hoffmann, C. Szekat, B. Rudd, and G. Bierbaum. 2006. The lantibiotic mersacidin is an autoinducing peptide. Appl. Environ. Microbiol. 72:7270-7277. Kruszewska, D., H.-G. Sahl, G. Bierbaum, U. Pag, S.O. Hynes, and Å. Ljungh. 2004. Mersacidin eradicates methicillin-resistant Staphylococcus aureus (MRSA) in a mouse rhinitis model. J. Antimicrob. Chemother. 54:648-653. Schaaff, F., G. Bierbaum, N. Baumert, P. Bartmann, and H.-G. Sahl. 2003. Mutations are involved in emergence of aminoglycoside-induced small colony variants of Staphylococcus aureus. Int. J. Med. Microbiol. 293:427-435. Szekat C., R.W. Jack, D. Skutlarek, H. Färber, and G. Bierbaum. 2003. Construction of an expression system for site-directed mutagenesis of the lantibiotic mersacidin. Appl. Environ. Microbiol. 69:3777-3783. Hsu S.T., E. Breukink, G. Bierbaum, H.-G. Sahl, B. de Kruijff, R. Kaptein, N.A. van Nuland, and A.M. Bonvin. 2003. NMR study of mersacidin and lipid II interaction in DPC micelles: Conformational changes are a key to antimicrobial activity. J. Biol. Chem. 278:13110-13117. Reipert A., K. Ehlert, T. Kast, and G. Bierbaum. 2003. Morphological and genetic differences in two isogenic Staphylococcus aureus strains with decreased susceptibilities to vancomycin. Antimicrob. Agents Chemother. 47:568-576. Schaaff, F., A. Reipert, and G. Bierbaum. 2002. An elevated mutation frequency favors development of vancomycin resistence in Staphylococcus aureus. Antimicrob. Agents Chemother. 46:3540-3548. Majer, F., D.G. Schmid, K. Altena, G. Bierbaum, and T. Kupke. 2002. The flavoprotein MrsD catalyzes the oxidative decarboxylation reaction involved in formation of the peptidoglycan biosynthesis inhibitor mersacidin. J. Bacteriol. 184:1234-1243. Guder, A., T. Schmitter, I. Wiedemann, H.-G. Sahl, and G. Bierbaum. 2002. Role of the single regulator MrsR1 and the two-component system MrsR2/K2 in the regulation of mersacidin production and immunity. Appl. Environ. Microbiol. 68:106-113. Lenz, W., N. Blümel, G. Bierbaum, B. Herding-Sotzek und P.M. Shah. 2001. Resistenzentwicklung bei S. aureus und Typenwechsel bei MRSA-Stämmen. Chemotherapie Journal 5:176-182. Lee, H.J., J.T. Suh, Y.S. Kim, W. Lenz, G. Bierbaum, and K.P. Schaal. 2001. Typing and antimicrobial susceptibilities of methicillin resistant Staphylococcus aureus (MRSA) Strains Isolated in a Hospital in Korea. J. Korean Med. Sci.16:381-385. Wiedemann, I., E. Breukink, C. van Kraaij C., O.P. Kuipers, G. Bierbaum, B. de Kruijff, and H.-G. Sahl. 2001. Specific binding of nisin to the peptidoglycan precursor lipid II combines pore formation and inhibition of cell wall biosynthesis for potent antibiotic activity. J. Biol. Chem.276:1772-1779. Altena, K., A. Guder, C. Cramer, and G. Bierbaum. 2000. Biosynthesis of the lantibiotic mersacidin: organization of a type B lantibiotic gene cluster. Appl. Environ. Microbiol. 66:2565-2571. Beukes, M., G. Bierbaum, H.-G. Sahl, and J.W. Hastings. 2000. Purification and partial characterization of a murein hydrolase, millericin B produced by Streptococcus milleri NMSCC 061. 66:23-28. Dommke, A., W. Lenz, G. Bierbaum, and H. Werner. 2000. Typisierung von Staphylococcus-aureus-Isolaten bei intensivpflichtigen Patienten. Hyg. Med. 25:129-134 Bierbaum, G., K. Fuchs, W. Lenz, C. Szekat, and H.-G. Sahl. 1999. Presence of Staphylococcus aureus with reduced susceptibility to vancomycin in Germany. Eur. J. Clin. Microbiol. Infect. Dis. 18:691-696. Pag, U., C. Heidrich, G. Bierbaum, and H.-G. Sahl. 1999. Molecular analysis of expression of the lantibiotic Pep5 immunity phenotype. Appl. Environ. Microbiol. 65.591-598. Sahl, H.-G., and G. Bierbaum. 1998. Lantibiotics: biosynthesis and biological activities of uniquely modified peptides from gram-positive bacteria. Annu. Rev. Microbiol. 52:41-79. Brötz, H., M. Josten, I. Wiedemann, U. Schneider, F. Götz, G. Bierbaum, and H.-G. Sahl. 1998. Role of lipid-bound peptidoglycan precursors in the formation of pores by nisin, epidermin and other lantibiotics. Mol. Microbiol. 30:317-327. Heidrich, C., U. Pag, M. Josten, J. Metzger, R.W. Jack, G. Bierbaum, G. Jung, and H.-G. Sahl. 1998. Isolation, characterization, and heterologous expression of the novel lantibiotic epicidin 280 and analysis of its biosynthetic gene cluster. Appl. Environ. Microbiol. 64:3140-3146. Brötz, H., G. Bierbaum, K. Leopold, P.E. Reynolds, and H.-G. Sahl. 1998. The lantibiotic mersacidin inhibits peptidoglycan synthesis by targeting lipid II. Antimicrob. Agents Chemother. 42:154-160. Brötz, H., G. Bierbaum, P.E. Reynolds, and H.-G. Sahl. 1997. The lantibiotic mersacidin inhibits peptidoglycan biosynthesis at the level of transglycosylation. Eur. J. Biochem. 246:193-199. Neis, S., G. Bierbaum, M. Josten, U. Pag, C. Kempter, G. Jung, and H.-G. Sahl. 1997. Effect of leader peptide mutations on biosynthesis of the lantibiotic Pep5. FEMS Microbiol. Lett. 149:249-255. Molitor, E., C. Kluczny, H. Brötz, G. Bierbaum, R.W. Jack, and H.-G. Sahl. 1996. Effects of the lantibiotic mersacidin on the morphology of staphylococci. Zentralbl. Bakteriol. 284:318-328. Heidrich, C., K. Hantke, G. Bierbaum, and H.-G. Sahl. 1996. Identification and analysis of a gene cluster encoding a Fur-like protein of Staphylococcus epidermidis. FEMS Microbiol. Lett. 140:253-259. Kuipers, O.P., G. Bierbaum, B. Ottenwälder, H.M. Dodd, N. Horn, J. Metzger, T. Kupke, V. Gnau, R. Bongers, P. van den Bogaard, H. Kosters, H.S. Rollema, W.M. de Vos, R.J. Siezen, G. Jung, F. Götz, H.-G. Sahl, and M.J. Gasson. 1996. Protein engineering of lantibiotics. Antonie Van Leeuwenhoek 69:161-169. Review. Bierbaum, G., F. Götz, A. Peschel, T. Kupke, M. van de Kamp, and H.-G. Sahl. 1996. The biosynthesis of the lantibiotics epidermin, gallidermin, Pep5, and epilancin K7. Antonie Van Leeuwenhoek 69:119-127. Bierbaum, G., C. Szekat, M. Josten, C. Heidrich, C. Kempter, G. Jung, and H.-G. Sahl. 1996. Engineering of a novel thioether bridge and role of modfied residues in the lantibiotic Pep5. Appl. Environ. Microbiol. 62:385-392. Jack, R.W., G. Bierbaum, C. Heidrich, and H.-G. Sahl. 1995. The genetics of lantibiotic biosynthesis. Bioassays 17:793-802. Meyer, C., G. Bierbaum, C. Heidrich, M. Reis, J. Süling, M.I. Iglesias-Wind, C. Kempter, E. Molitor, and H.-G. Sahl. 1995. Nucleotide sequence of the lantibiotic Pep5 biosynthesis gene cluster and functional analysis of PepP and PepC. Evidence for a role of PepC in thioether formation. Eur. J. Biochem. 232:478-489. Sahl, H.-G., R.W. Jack, and G. Bierbaum. 1995. Biosynthesis and biological activities of lantibiotics with unique post-translational modifications. Eur. J. Biochem. 230:827-853. van de Kamp, M., H.W. van den Hooven, R.N. Konings, G. Bierbaum, H.-G. Sahl, O.P. Kuipers, R.J. Siezen, W.M. de Vos, C.W. Hilbers, and F.J. van de Ven. 1995. Elucidation of the primary structure of the lantibiotic epilancin K7 from Staphylococcus epidermidis K7. Cloning and characterization of the epilancin-K7-encoding gene and NMR analysis of mature epilancin K7. Eur. J. Biochem. 230:587-600. Bierbaum, G., H. Brötz, K.P. Koller, and H.-G. Sahl. 1995. Cloning, sequencing and production of the lantibiotic mersacidin. FEMS Microbiol. Lett. 127:121-126. Brötz, H., G. Bierbaum, A. Markus, E. Molitor, and H.-G. Sahl. 1995. Mode of action of the lantibiotic mersacidin: inhibition of peptidoglycan biosynthesis via a novel mechanism? Antimicrob. Agents Chemther. 39:714-719. Bierbaum, G., M. Reis, C. Szekat, and H.-G. Sahl. 1994. Construction of an expression system for engineering of the lantibiotic Pep5. Appl. Environ. Microbiol. 60:4332-4328. Bierbaum, G., M. Karutz, D. Weuster-Botz, and C. Wandrey. 1994. Production of protease with Bacillus licheniformis mutants insensitive to repression of exoenzyme biosynthesis. Appl. Microbiol. Biotechnol. 40:611617. Bierbaum, G., and H.-G. Sahl. 1993. Lantibiotics - unusually modified bacteriocin-like peptides from gram-positive bacteria. Zentralbl. Bakteriol. 278:1-22. Giesecke, U.E., G. Bierbaum, H. Rudde, U. Spohn, and C. Wandrey. 1991. Production of alkaline protease with Bacillus licheniformis in a controlled fed-batch process. Appl. Microbiol. Biotechnol. 35:720-724. Bierbaum, G., U.E. Giesecke, and C. Wandrey. 1991. Analysis of nucleotide pools during protease production with Bacillus licheniformis. Appl. Microbiol. Biotechnol. 35:725-730. Bierbaum, G., and H.-G. Sahl. 1989. Influence of cationic peptides on the activity of the autolytic endo-beta-N-acetylglucosaminidase of Staphylococcus simulans 22. FEMS Microbiol. Lett. 49:223-227. Sahl, H.-G., H. Ersfeld-Dressen, G. Bierbaum, M. Josten, M. Kordel, M. Reis, and F. Schüller. 1987. Different mechanisms of insensitivity to the staphylococcin-like peptide Pep5. Zentralbl. Bakteriol. Mikrobiol. Hyg. [A] 267:173-185. Bierbaum, G., and H.-G. Sahl. 1987. Autolytic system of Staphylococcus simulans 22: influence of cationic peptides on activity of N-acetylmuramoyl-L-alanine amidase. J. Bacteriol. 169:5452-5458. Bierbaum, G., and H.-G. Sahl. 1985. Induction of autolysis of staphylococci by the basic peptide antibiotics Pep5 and nisin and their influence on the activity of autolytic enzymes. Arch. Microbiol. 141:249-254.
Patents: Giesecke, U.E., G. Bierbaum und C. Wandrey: Verfahren zur Gewinnung von alkalischer SerinProtease durch ammoniumlimitierte Fermentation von Bacillus-Stämmen. Deutsches Patent Nr. 39 21 764 Koller, H.P., G. Bierbaum und H.-G. Sahl: Recombinant mersacidin and a method for production. US Patent 5667991 Koller, H.P., G. Bierbaum und H.-G. Sahl: Recombinant mersacidin and a method for production. Europäische Patentanmeldung Nr. 94 114 298.6 Dawson M. J., J. Cortes Bargallo, B.A.M. Rudd, S. Boakes, G. Bierbaum, A. Hoffmann, S. Schmitz: Production of mersacidin and its variants in sigH and/or mrsA negative Bacillus subtilis host cells. Patent WO 2005/093069 A2
Book Chapters:Bierbaum, G., R. W. Jack, and H.-G. Sahl: 560. Lantibiotic leader peptidases. In: Handbook of proteolytic enzymes (A. Barret, N. D. Rawlings, J. F. Woessner, Hsg.), 1st (1998) and 2nd Edition, Elsevier Ltd., S. 1815-1817 (2004) Jack, R. W., G. Bierbaum and H.-G. Sahl: 387. Translocator-associated peptidases. In: Handbook of proteolytic enzymes (A. Barret, N. D. Rawlings, J. F. Woessner, Hsg.), 1st (1998) and 2nd Edition, Elsevier Ltd., S. 1253-1257 (2004) Bartmann, P., G. Bierbaum , H.-G. Sahl, W. Witte: Staphylokokkeninfektionen. In: Handbuch Infektionen bei Kindern und Jugendlichen, 4. Auflage (Deutsche Gesellschaft für pädiatrische Infektiologie e.V., Hsg.), Futuramed Verlag, München 640-644 (2003) Bierbaum, G.: Mersacidin – ein neues (L)antibiotikum. Bioforum 26, 464-465 (2003) Bierbaum, G.: 17. Genetics of lantibiotic biosynthesis. In: Comprehensive Natural Products Chemistry, Bd.4 (D. Barton, K. Nakanishi, O. Meth-Cohn, J. W. Kelly, Hsg.), Elsevier Science, Oxford, S. 275-304 (1999) Bierbaum, G.: Antibiotische Peptide - Lantibiotika. Chemotherapie Journal 8, 204-209 (1999) Bierbaum, G. 1999. Genetics of lantibiotic biosynthesis. p. 275-254. In: J.W. Kelly (ed.), volume 4, Amino acids, peptides, prophyrins, and alkaloids. Amsterdam: Elsevier. Bierbaum, G., H. Brötz, and H.-G. Sahl. 1997. Lanthionine-containing antibiotic peptides (lantibiotics): Features, functions and prespectives. Biospektrum 2:51-55. Bierbaum, G., H. Brötz, and H.-G. Sahl. 1996. Modes of action of lantibiotics, p. 125-134. In: S.G. Pandalai (ed.), Recent Research Developments in Antimicrobial Agents and Chemotherapy. Trivandrum: Research Signpost. Book:Jack, R.W., G. Bierbaum, and H.-G. Sahl. 1998. Lantibiotics and related peptides. Springer Verlag, Berlin, Heidelberg, New York. ISBN: 3-540-63600-5
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